The Priapus Shot (P-Shot): Your Guide to PRP for Erectile Dysfunction

(A deep dive into platelet-rich plasma therapy for male sexual health)

Struggling with erectile dysfunction and seeking a natural, non-surgical solution? The Priapus Shot, popularly known as the P-Shot London, is revolutionizing male sexual health by harnessing the body’s own healing power.

At Eskulap Clinic in Maple Cross, Rickmansworth it is a popular topic. Amongst our patients it has emerged as a highly-discussed, non-surgical option for men seeking to address issues like Erectile Dysfunction (ED) and Peyronie’s Disease. Named after the Greek god of fertility, Priapus, this treatment leverages the body’s natural healing mechanisms through Platelet-Rich Plasma (PRP) therapy for potential penile rejuvenation.

This guide delves deep into everything you need to know about this innovative regenerative medicine for men.

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P-Shot in Maple Cross, Rickmansworth

Erectile dysfunction (ED) affects millions of men worldwide and is often a source of frustration, relationship strain and reduced quality of life. Beyond pills and devices, regenerative medicine is now offering new possibilities — one of the most talked-about being the P-Shot (Priapus Shot).

This injection-based therapy uses your own blood’s platelets to stimulate penile tissue repair, improve blood flow and, theoretically, restore erectile function.

In this article we’ll explore what the P-Shot treatment is, how it works, who it may help, what the evidence says, the risks and costs, and how to decide whether it might be right for you.

Michał Kisiel
Aesthetic Practitioner & Trichologist

What is the P-Shot / Priapus Shot?

The P-Shot is a proprietary, branded treatment that utilizes Platelet-Rich Plasma (PRP) derived from the patient’s own blood. It is classified as an autologous, regenerative therapy, meaning the material used for injection comes directly from the individual receiving the treatment.

The process typically involves drawing a sample of your blood, spinning it in a centrifuge to concentrate the platelets (and growth factors), then injecting that concentrated plasma into the shaft, glans or base of the penis. Proponents call it “penile tissue regeneration” or “penile rejuvenation”, and it is marketed as a non-surgical alternative to more invasive treatments.

The name “Priapus” draws from the Greek god of fertility and male virility, and the P-Shot brand has become well known in men’s sexual health clinics. The theoretical mechanism is that the growth factors in PRP may promote angiogenesis (new blood vessels), nerve regeneration, reduction of fibrosis, improved tissue elasticity and thus improved erectile function, penile girth, sensitivity and potentially length.

Unlike medications that temporarily improve blood flow, the P-Shot aims to rejuvenate penile tissue at a cellular level, offering a potential long-term natural ED solution.

Indications: Who is it for?

The concept of the P-Shot was pioneered by Dr. Charles Runels, who adapted the well-known PRP technique, traditionally used in orthopedics and aesthetics (like the “Vampire Facial”), for male sexual health.

The main use of the P-Shot is for men with erectile dysfunction — in particular those with mild to moderate ED, often with a vascular component where there’s residual erectile ability. For many men the appeal is that it may go beyond symptom management (like PDE-5 inhibitors) and aim at repairing underlying tissue damage.

Primary Application: The injection is used to treat male sexual dysfunction, particularly improving the ability to get and maintain an erection (Erectile Dysfunction).

Penile curvature and Peyronie’s disease: Some clinics also use the P-Shot for men with scar tissue or curvature (Peyronie’s disease) because the theory holds that PRP may reduce fibrosis and improve penile architecture.
Enhancement claims (length, girth, sensation): Marketing often emphasises improved girth/length, greater sensitivity, improved stamina and sexual performance. However, the clinical evidence to support enlargement claims is weak and should be treated cautiously.

Here’s the simple science about the P-Shot:

The goal is to restore the natural mechanisms for achieving harder erections and improve overall sexual performance.

Ideal candidate vs less ideal

Men most likely to benefit tend to have:

Some residual erectile response (not complete impotence)
Good vascular health (no severe atherosclerosis)
Non-smokers, no uncontrolled diabetes
Realistic expectations

Men less likely to benefit:

Severe ED with no response to medications/devices
Long-standing diabetes, severe vascular disease, nerve injury
Younger men chasing “enhancement” rather than functional repair

The Priapus Shot (P-Shot London): PRP for Erectile Dysfunction

Plasma injection into the penis. Known as the P-Shot London. Check out aesthetic gynecology treatments at the Eskulap Clinic on Maple Cross Rickmansworth.

The Priapus Shot (P-Shot London): PRP for Erectile Dysfunction

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How P-Shot Works?

(What happens during the P-Shot?)

Before injection, a topical numbing cream or a local anesthetic (penile block) is applied to minimize discomfort. The PRP is then carefully injected into specific areas of the penis, most notably the corpus cavernosum (the spongy erectile tissue) and the head (glans).

Blood draw: A vial (typically 10 ml) is taken from your arm. Some protocols emphasise higher volume for better platelet yield.
Centrifugation: The blood is spun to separate red cells, plasma and platelets; sometimes a further concentration step is used.
Activation and preparation: In some cases it is possible to “activate” the PRP to form a fibrin matrix or richer mixture. The clinician extracts the pure, concentrated PRP, which contains a powerful mix of growth factors (such as PDGF, VEGF, and TGF
Injection: After topical numbing (and sometimes nerve block), the PRP is injected intracavernosally into the penis. The number of injection sites and total volume vary.
Adjuncts: Sometimes it is recommended using a vacuum erection device (VED) or vacuum pump following the injection, or combining with low-intensity shock wave therapy (Li-SWT) for synergy.

The entire process is minimally invasive, and patients can usually return to their daily activities immediately afterward.

The growth factors in the injected PRP are theorized to:

Stimulate Tissue Regeneration: Encourage the multiplication of healthy cells and the repair of damaged tissue.
Promote Angiogenesis: Trigger the formation of new fine blood vessels (neovascularization), which increases blood flow to the penis— this enhances vascular health – a crucial factor in addressing vascular ED.
Activate Stem Cells: Recruit existing stem cells in the tissue to aid in the long-term repair process.
The therapy can also stimulate the regeneration of neural and endothelial tissues, which may enhance sensitivity.

Men opt for the Priapus Shot for a variety of reasons, with benefits extending beyond just erection quality:

Improved Erection Hardness and Quality:The primary benefit is significantly harder erections due to better blood flow.
Enhanced Sensation:Many patients report increased sensitivity, leading to greater sexual satisfaction.
Potential for Increased Size:Some men experience a slight increase in girth as new tissue forms, a process often referred to as penile rejuvenation.
Natural and Safe:As it uses your own blood, the risk of allergic reactions or rejection is minimal, making it a very safe non-surgical ED procedure.

Recovery Timeline and Expected Results

The entire treatment session usually takes less than 30-45 minutes, and many men have minimal downtime. It is advised to take some time to fully recover before returning to normal activity (and even intercourse).

While a single shot may yield results, a series of 2-3 treatments spaced 4-8 weeks apart is often recommended, especially for more severe ED or Peyronie’s disease.

Optimal results often appear after 4-6 weeks, and the effects can last for up to 1-2 years. Treatment is often compared to Viagra in terms of effectiveness but works through a fundamentally different, regenerative mechanism.

You need to remember that despite the positive anecdotal accounts and testimonials, the P-Shot remains an experimental treatment due to a lack of robust, high-quality clinical data.

On average, PRP injections in ED show modest improvements in validated erectile function scores (IIEF-EF) compared with baseline and placebo.
Safety profile appears favourable (minor side-effects, no major adverse events reported in current studies).
But effect sizes (~2-4 points on IIEF) are relatively small, and clinical significance (i.e., patient-perceived meaningful improvement) varies.
Evidence for improvements in penile length/girth, long-term durability of effect (>1-2 yrs), or in severe ED is lacking.

What you should expect

Realistic outcome: improved erectile quality and possibly improved rigidity/sensation; size increases are not guaranteed.
Time frame: some men see changes within weeks, others months; some may require multiple sessions.
Duration: benefits may last 12-18 months or more, but repeat treatments may be needed.
No downtime is typical, but combining a VED/pump and optimising health improves chances.

Lifestyle optimisation

To get the most out of any regenerative therapy (including P-Shot), address:

Cardiovascular health (blood pressure, lipids)
Smoking cessation
Weight management and exercise
Testosterone/hormone levels
Avoid heavy alcohol use and recreational drugs

Control diabetes, optimise sleep, reduce stress

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Safety and Potential Side Effects

In short, the P-Shot is not yet approved by the FDA specifically for treating ED, and patients should be aware that the efficacy of this non-surgical ED solution is not fully proven.

Since the PRP is derived from the patient’s own blood (autologous), the risk of allergic reaction or disease transmission is virtually eliminated, contributing to its strong safety profile.

You may experience mild swelling, bruising or discomfort at the injection site for a short period. These usually resolve within a day or two. Serious complications are rare when performed by an experienced professional.

Cost of P-Shot and Alternatives

The cost of P Shot varies based on your location and the provider’s expertise, typically ranging from 500 to 2500. Since it is generally considered an elective procedure, it is not usually covered by insurance.

The P-Shot cost can be substantial, often ranging from hundreds to thousands of pounds per session, with multiple sessions frequently recommended.
Alternative Treatments: For a proven approach to ED, men may consider oral medications (Viagra, Cialis), penile injections (TriMix), and low-intensity shockwave therapy (LITS). The P-Shot is sometimes combined with acoustic wave treatment for potentially enhanced results.

Before pursuing the P-Shot, a thorough consultation with a urologist or a male sexual health specialist is essential to determine if it is a suitable, realistic, and safe option for your specific case of male sexual dysfunction.

Price List

Penis PRP Compared to conventional ED treatments

PDE-5 inhibitors (sildenafil, tadalafil etc) are first-line, with robust evidence, low cost and regulatory approval.
Vacuum erection devices, penile injections (alprostadil/Trimix), penile implants remain standard options for more severe or refractory ED.
The P-Shot may be considered adjunctive or alternative, but not yet replacement for established therapies.
Some studies suggest combining PRP with low-intensity shock wave therapy (Li-SWT) may enhance outcomes.
Use of vacuum devices/pumps following PRP injection may enhance tissue remodeling and maximise benefit (per clinic protocols).
Lifestyle factors (weight loss, exercise, smoking cessation, optimise testosterone, treat diabetes/hypertension) remain foundational.

Frequently Asked Questions (FAQs)

Q: How long do the results of the P-Shot last? A: Results can last from 12 to 24 months. Lifestyle factors and age can influence longevity.

Q: Is the P-Shot painful? A: Discomfort is minimal. Topical anesthetics are used to numb the area, making the injection feel like a quick pinch.

Q: How does the P-Shot compare to Shockwave Therapy? A: Both are non-surgical. Shockwave therapy uses acoustic waves to stimulate blood vessel growth, while the P-Shot injects growth factors directly. They are often combined for synergistic results.

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Conclusion

If you live in Rickmansworth, Maple Cross, Gerrards Cross, Chorleywood, Watford visit Eskulap Aesthetic Medicine Clinic today. Book your consultation and learn why the Priapus Shot (P-Shot) represents a significant advance in treating erectile dysfunction. By leveraging your body’s natural healing capabilities, it offers a promising path to improved sexual health, sensation, and confidence. If you’re looking for an alternative to pharmaceuticals or invasive surgery, consulting with a knowledgeable healthcare provider about the P-Shot could be your first step toward reclaiming your sexual well-being.